PLASMA INSULIN ACTIVITY FOLLOWING THE ADMINISTRATION OF BZ 55 (N-SULFANYLYL-N'-n-BUTYLCARBAMIDE) IN DOGS

Neoplasms in purebred boxer dogs following long-term administration of N-methyl-N-nitrosourea.

The carcinogenicity of N-methyl-N-nitrosourea (MNU) has been demonstrated in several species for a variety of tissues, particularly the nervous system. Boxer dogs, a breed with a high incidence of spontaneous tumors (in cluding brain tumors), were exposed to MNU to determine their susceptibility to MNU and to compare the induced tumors with the types of tumors reported in the literature. Twenty...

MNDO Study of Nitrogen Atom Inversion in Piperazine, N,N'-Dimethylpiperazine and N,N'-Dichloropiperazine

MNDO semi-empirical SCF MO calculations are used to study the pyramidal nitrogen atom inversion and configurational equilibria in the title compounds.

Enhancement of gastric carcinogenesis in dogs given N-methyl-N'-nitro-N-nitrosoguanidine following vagotomy.

In an attempt to improve the method of induction of gastric cancer in dogs, selective vagotomy without drainage procedure was performed before administration of Nmethyl-N †̃-nitmo-N-nitrosoguanidine(MNNG). Twenty dogs were divided into two groups of 10 dogs (five beagles and five mongrels). The control group received MNNG alone. Dogs of the experimental group were vagotomized 2 months before a...

Maciej Zukowski - n. 55

Nanoparticles Prepared From N,N-Dimethyl-N-Octyl Chitosan as the Novel Approach for Oral Delivery of Insulin: Preparation, Statistical Optimization and Characterization

In this study, N,N-Dimethyl-N-Octyl chitosan was synthesized. Nanoparticles containing insulin were prepared using PEC method and were statistically optimized using the Box-Behnken response surface methodology. The independent factors were considered to be the insulin concentration, concentration and pH of the polymer solution, while the dependent factors were characterized as the size, zeta po...